A Microfluidic Cross-Slot Device for Measurement of Erythrocyte Deformability
نویسندگان
چکیده
Red blood cell (RBC) deformation is a dominant factor in the rheological properties of blood in vessels smaller than 300 micrometers. A reduction in cell deformability is associated with health conditions such as malaria and diabetes. The extensional flow within a microfluidic cross-slot microchannel has been proposed as a mechanism for measuring the deformation of cells. Three-dimensional simulations of red blood cell deformation in a microfluidic cross-slot channel are presented, suggesting the device has the capability of measuring both cell stiffness and viscosity.
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